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ea0029p1423 | Pituitary Clinical | ICEECE2012

Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study

Claessen K. , Ramautar S. , Pereira A. , Smit J. , Roelfsema F. , Romijn H. , Kroon H. , Kloppenburg M. , Biermasz N.

Background: Leiden University Medical Center, Leiden, The Netherlands; 2Leiden University Medical Center, Leiden, The Netherlands; 3Leiden University Medical Center, Leiden, The NetherlandsBackground: Arthropathy is an invalidating complication of acromegaly, despite persisting biochemical disease control, which has a high impact on the quality of life (QoL). The prognosis and determinants are currently unknown.<p class="abstext...

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ea0020p545 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Pre-treatment IGF-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease

Biermasz Nienke R , Wassenaar Moniek J E , van der Klaauw Agatha A , Pereira Alberto M , Smit Johannes W A , Roelfsema Ferdinand , Wolterbeek Ron , Kroon Herman M , Kloppenburg Margreet , Romijn Johannes A

Objective: To identify factors influencing the development of osteoarthritis during long-term control of acromegaly, focusing on disease specific parameters, growth hormone (GH) and insulin-like growth factor I (IGF-I) concentrations and duration of disease, adjusted for the well-known determinants of primary osteoarthritis.Design: Follow-up study.Methods: We studied 67 patients, with adequate biochemical control of acromegaly for ...

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ea0020p552 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The D3 GH receptor polymorphism is associated with osteoarthritis, especially of the hip, in patients with long-term cured acromegaly

Wassenaar Moniek JE , Biermasz Nienke R , van der Klaauw Agatha A , Smit Johannes WA , Pereira Alberto M , Roelfsema Ferdinand , van der Straaten Tahar , Kroon Herman M , Kloppenburg Margreet , Guchelaar HJ , Romijn Johannes A

Objective: To evaluate the impact of the genomic deletion of exon 3 in the growth hormone receptor (d3GHR) on co-morbidities of acromegaly in a well-characterized cohort of patients with long-term remission of acromegaly.Design: Cross sectional study.Methods: The presence of the d3GHR polymorphism was assessed in 86 acromegalic patients and related to clinical outcome, i.e. anthropometric parameters, osteoarthritis, and the metabol...

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Endocrine Abstracts

Progression of acromegalic arthropathy despite long-term biochemical control: a prospective, radiological study

Pre-treatment IGF-I concentrations predict radiographic osteoarthritis in acromegalic patients with long-term cured disease

The D3 GH receptor polymorphism is associated with osteoarthritis, especially of the hip, in patients with long-term cured acromegaly

BiosciAbstracts